profound change in sensibility

profound apprehension
深い懸念、根強い不安

profound blindness
全盲

profound change
重大な［根底からの］変化

profound change in sensibility
《a ～》感受性の重大な変化

profound changes brought about by the digitalization
デジタル化がもたらす大きな変化

profound changes taking place in
～で起きている深遠な変革