Go and wash your hands. They're absolutely filthy.

The children were filthy after playing in the mud. 
子どもたちは泥遊びをした後、汚れていた。

Get that filthy animal out of here. 
その汚い動物をどっかやってくれ。

Take your filthy hands off me! 
その汚い手を離してよ！

You're filthy!
あなたなんか不潔よ！

Go and wash your hands. They're absolutely filthy.