Life has its ups and downs.

through life's ups and downs
人生の浮き沈みを通して［経験して］

affected by economic ups and downs
《be ～》景気に左右される

affected by the ups and downs of the stock market
《be ～》株式相場の変動［浮き沈み］に影響される

After a few ups and downs, his novel ended up being published.
多少の紆余曲折の後、結局彼の小説は出版された。

We've had our ups and downs, but we are still the best of friends. 
いろいろなことがあったが、私たちは今でも親友です。

There have been many ups and downs.
これまでに良いことも悪いこともいろいろあった。

Life has its ups and downs. 
Life is full of ups and downs. 
人生は山あり谷あり。
七転び八起き。

My husband and I have had our share of ups and downs. 
主人と私は良い時も悪い時をも分かち合ってきました。

Sometimes we have our ups and downs.
人生には浮き沈みがあります。