You seem to be having trouble.

You seem to be forgetting something.
あなたは何か忘れているようですね。

You seem to be having fun.
楽しそうですね。

You seem to be having trouble.
お困りのようですね。

You seem to be in low spirits today.
今日は塞ぎ込んでるね。

You seem to have changed a bit since last we met.
最後に会った時からだいぶ変わったね。

You seem to have matured.
大人っぽくなったね。